abstract：BACKGROUND:Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects. OBJECTIVE:A study was conducted to establish ...

journal_title：Journal of inflammation (London, England)

authors： Dixit VD,Yang H,Sayeed KS,Stote KS,Rumpler WV,Baer DJ,Longo DL,Mattson MP,Taub DD

更新日期：2011-03-07 00:00:00

abstract：: Allogeneic human mesenchymal stem cells (hMSCs) can suppress graft versus host disease (GvHD) and have profound anti-inflammatory and regenerative capacity in stroke, infarct, spinal cord injury, meniscus regeneration, tendinitis, acute renal failure, and heart disease in human and animal models of disease. There is ...

journal_title：Journal of inflammation (London, England)

authors： Bonfield TL,Nolan Koloze MT,Lennon DP,Caplan AI

更新日期：2010-10-25 00:00:00

abstract：: The limitations of steroidal and non steroidal anti-inflammatory drugs have prompted investigation into other biologically based therapeutics, and identification of immune selective anti-inflammatory agents of salivary origin. The traditional view of salivary glands as accessory digestive structures is changing as th...

journal_title：Journal of inflammation (London, England)

authors： Mathison RD,Davison JS,Befus AD,Gingerich DA

更新日期：2010-09-28 00:00:00

abstract：: Tumor necrosis factor alpha (TNF-alpha)is a host inflammatory factor. Bacteria increase TNF-alpha expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer. It is unknown, however, how TNF-alpha directly modulates bacterial protein expression during intestinal in...

journal_title：Journal of inflammation (London, England)

authors： Ma J,Zhang YG,Xia Y,Sun J

更新日期：2010-08-12 00:00:00

abstract：BACKGROUND:The metabolic syndrome (MetS) is associated with the presence of low grade inflammation. Our aim was to analyze the inter-relations between each of the components of the metabolic syndrome (MetS) and four inflammatory markers, namely high sensitivity C-reactive protein (hs-CRP), the erythrocyte sedimentation...

journal_title：Journal of inflammation (London, England)

authors： Rogowski O,Shapira I,Bassat OK,Chundadze T,Finn T,Berliner S,Steinvil A

更新日期：2010-07-26 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonar...

journal_title：Journal of inflammation (London, England)

authors： Arunachalam G,Sundar IK,Hwang JW,Yao H,Rahman I

更新日期：2010-07-22 00:00:00

abstract：BACKGROUND:The key co-repressor complex components HDAC-2, Mi-2alpha/beta and mSin3a are all critical to the regulation of gene transcription. HDAC-2 function is impaired by oxidative stress in a PI3Kdelta dependant manner which may be involved in the chronic glucocorticoid insensitive inflammation in the lungs of COPD...

journal_title：Journal of inflammation (London, England)

authors： Marwick JA,Stevenson CS,Chung KF,Adcock IM,Kirkham PA

更新日期：2010-07-16 00:00:00

abstract：BACKGROUND:Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension. METHODS:Left ventricle mR...

journal_title：Journal of inflammation (London, England)

authors： Miguel-Carrasco JL,Zambrano S,Blanca AJ,Mate A,Vázquez CM

更新日期：2010-05-12 00:00:00

abstract：BACKGROUND:Hemorrhagic shock/resuscitation is associated with aberrant neutrophil activation and organ failure. This experimental porcine study was done to evaluate the effects of Fas-directed extracorporeal immune therapy with a leukocyte inhibition module (LIM) on hemodynamics, neutrophil tissue infiltration, and tis...

journal_title：Journal of inflammation (London, England)

authors： Lögters TT,Altrichter J,Paunel-Görgülü A,Sager M,Witte I,Ott A,Sadek S,Baltes J,Bitu-Moreno J,Schek A,Müller W,Jeri T,Windolf J,Scholz M

更新日期：2010-04-20 00:00:00

abstract：BACKGROUND:Urinary bladder and renal dysfunction are secondary events associated with spinal cord injury (SCI) in humans. These secondary events not only compromise quality of life but also delay overall recovery from SCI pathophysiology. Furthermore, in experimental models the effects of SCI therapy on bladder and ren...

journal_title：Journal of inflammation (London, England)

authors： Shunmugavel A,Khan M,Te Chou PC,Dhindsa RK,Martin MM,Copay AG,Subach BR,Schuler TC,Bilgen M,Orak JK,Singh I

更新日期：2010-04-19 00:00:00

abstract：BACKGROUND:PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cells derived from PTPH1-...

journal_title：Journal of inflammation (London, England)

authors： Patrignani C,Lafont DT,Muzio V,Gréco B,Hooft van Huijsduijnen R,Zaratin PF

更新日期：2010-03-30 00:00:00

abstract：BACKGROUND:CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS:Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequence...

journal_title：Journal of inflammation (London, England)

authors： Wang Y,Cui L,Gonsiorek W,Min SH,Anilkumar G,Rosenblum S,Kozlowski J,Lundell D,Fine JS,Grant EP

更新日期：2009-11-11 00:00:00

abstract：BACKGROUND:Homocysteine (Hcy) and inflammatory cytokines have been linked to adverse outcomes in persons with cardiovascular and kidney diseases and recent reports suggest that cytokine-mediated inflammatory infiltrates may be an important contributor to the pathogenesis the aforementioned diseases. Although some repor...

journal_title：Journal of inflammation (London, England)

authors： Shastry S,James LR

更新日期：2009-09-26 00:00:00

abstract：BACKGROUND:The pleiotropic protein MIF, (macrophage migration inhibitory factor), has been demonstrated to modulate several key proteins governing cell cycle control and is considered to contribute to cell growth and differentiation. In this study we investigated the effect of MIF on the expression and cellular distrib...

journal_title：Journal of inflammation (London, England)

authors： Taranto E,Xue JR,Morand EF,Leech M

更新日期：2009-08-24 00:00:00

abstract：: Interleukin-6 is a multifunctional cytokine that is critical for T/B-cell differentiation and maturation, immunoglobulin secretion, acute-phase protein production, and macrophage/monocyte functions. Extensive research into the biology of IL-6 has implicated IL-6 in the pathophysiology and pathogenesis of RA. An anti-...

journal_title：Journal of inflammation (London, England)

authors： Liang B,Song Z,Wu B,Gardner D,Shealy D,Song XY,Wooley PH

更新日期：2009-04-15 00:00:00

abstract：: We previously showed that the progression of burn-induced injury was inhibited by exposing the peripheral area of injured skin to sublethal hyperthermia following the burn. We called this phenomenon post-heat shock tolerance. Here we suggest a mechanism for this phenomenon. Exposure of the peripheral primary hyperalg...

journal_title：Journal of inflammation (London, England)

authors： Shahabi S,Hassan ZM,Jazani NH

更新日期：2009-03-27 00:00:00

abstract：BACKGROUND:Circulating 25 hydroxyvitamin D (25 (OH)D), an accurate measure of vitamin D status, is markedly greater in individuals with increased exposure to ultraviolet B (UVB) light via sunlight or the use of artificial UV light. Aside from the known relationship between vitamin D and bone, vitamin D has also been im...

journal_title：Journal of inflammation (London, England)

authors： Peterson CA,Heffernan ME

更新日期：2008-07-24 00:00:00

abstract：BACKGROUND:Bee venom therapy has been used to treat inflammatory diseases including rheumatoid arthritis in humans and in experimental animals. We previously found that bee venom and melittin (a major component of bee venom) have anti-inflammatory effect by reacting with the sulfhydryl group of p50 of nuclear factor-ka...

journal_title：Journal of inflammation (London, England)

authors： Park HJ,Lee HJ,Choi MS,Son DJ,Song HS,Song MJ,Lee JM,Han SB,Kim Y,Hong JT

更新日期：2008-05-29 00:00:00

abstract：BACKGROUND:Nuclear factor kappa B (NF-kappaB) has been shown to play an important role in regulating the expression of many genes involved in cell survival, immunity and in the inflammatory processes. NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an ...

journal_title：Journal of inflammation (London, England)

authors： Jones E,Adcock IM,Ahmed BY,Punchard NA

更新日期：2007-11-24 00:00:00

abstract：BACKGROUND:The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. METHODS:German landrace pigs under...

journal_title：Journal of inflammation (London, England)

authors： Abdel-Rahman U,Margraf S,Aybek T,Lögters T,Bitu-Moreno J,Francischetti I,Kranert T,Grünwald F,Windolf J,Moritz A,Scholz M

更新日期：2007-10-10 00:00:00

abstract：BACKGROUND:The Amazonian medicinal plant Sangre de grado (Croton palanostigma) has traditional applications for the treatment of wound healing and inflammation. We sought to characterize two extracts (progrado and zangrado) in terms of safety and oligomeric proanthocyanidin chain length. Additionally progrado was evalu...

journal_title：Journal of inflammation (London, England)

authors： Miller MJ,Bobrowski P,Shukla M,Gupta K,Haqqi TM

更新日期：2007-08-14 00:00:00

abstract：: Roots and stem-bark of Mahonia aquifolium (Oregon grape) (Berberidaceae) are effectively used in the treatment of skin inflammatory conditions.In the present study, the effect of Mahonia aquifolium crude extract and its two representative alkaloid fractions containing protoberberine and bisbenzylisoquinoline (BBIQ) a...

journal_title：Journal of inflammation (London, England)

authors： Rackova L,Oblozinsky M,Kostalova D,Kettmann V,Bezakova L

更新日期：2007-07-16 00:00:00

abstract：BACKGROUND:Monocytes and neutrophils are examples of phagocytic leukocytes, with neutrophils being considered as the 'chief' phagocytic leukocyte. Both monocytes and neutrophils have been implicated to play a key role in the development of ischaemia-reperfusion injury, where they are intrinsically involved in leukocyte...

journal_title：Journal of inflammation (London, England)

authors： Hughes SF,Hendricks BD,Edwards DR,Bastawrous SS,Roberts GE,Middleton JF

更新日期：2007-05-30 00:00:00

abstract：:Neonatal monocytes display immaturity of numerous functions compared with adult cells. Gene expression arrays provide a promising tool for elucidating mechanisms underlying neonatal immune function. We used a well-established microarray to analyze differences between LPS-stimulated human cord blood and adult monocytes...

journal_title：Journal of inflammation (London, England)

authors： Lawrence S,Tang Y,Frank MB,Dozmorov I,Jiang K,Chen Y,Cadwell C,Turner S,Centola M,Jarvis JN

更新日期：2007-02-16 00:00:00

abstract：BACKGROUND:The objective for this present study was to determine whether or not suspension bead array is a feasible method to detect changes in cytokine protein expression in mouse lung tissue homogenates. Here, we report on suspension bead array as a feasible method for detection of lipopolysaccharide (LPS)-evoked cha...

journal_title：Journal of inflammation (London, England)

authors： McDuffie E,Obert L,Chupka J,Sigler R

更新日期：2006-11-29 00:00:00

abstract：:Cathelicidins are mammalian proteins containing a C-terminal cationic antimicrobial domain. Porcine PR-39 cathelicidin affects leukocyte biology. Mechanisms of action may involve alteration of heparan sulfate proteoglycan-dependent functions in inflammatory cells. It was tested whether PR-39 affects human neutrophil m...

journal_title：Journal of inflammation (London, England)

authors： Djanani A,Mosheimer B,Kaneider NC,Ross CR,Ricevuti G,Patsch JR,Wiedermann CJ

更新日期：2006-11-02 00:00:00

abstract：BACKGROUND:124 triazolo [4, 3-a]18naphthyridine derivatives (including NF161 and NF177) were tested for anti-inflammatory, analgesic and antipyretic properties and for their effects on spontaneous locomotor activity in mice and acute gastrolesivity in rats. Both NF161 and NF177 appeared to be anti-inflammatory and anal...

journal_title：Journal of inflammation (London, England)

authors： Dianzani C,Collino M,Gallicchio M,Di Braccio M,Roma G,Fantozzi R

更新日期：2006-03-28 00:00:00

abstract：:French maritime pine bark extract (Pycnogenol) displays a variety of anti-inflammatory effects in vivo. Aim of this study was to determine whether human plasma after oral intake of Pycnogenol contains sufficient concentrations of active principles to inhibit key mediators of inflammation. Blood samples from seven heal...

journal_title：Journal of inflammation (London, England)

authors： Grimm T,Chovanová Z,Muchová J,Sumegová K,Liptáková A,Duracková Z,Högger P

更新日期：2006-01-27 00:00:00

abstract：:IkappaBalpha is an inhibitor of the nuclear transcription factor NF-kappaB. Binding of IkappaBalpha to NF-kappaB inactivates the transcriptional activity of NF-kappaB. Expression of IkappaBalpha itself is regulated by NF-kappaB, which provides auto-regulation of this signaling pathway. Here we present a mouse model fo...

journal_title：Journal of inflammation (London, England)

authors： Zhang N,Ahsan MH,Zhu L,Sambucetti LC,Purchio AF,West DB

更新日期：2005-10-05 00:00:00

abstract：BACKGROUND:The effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, on neutrophil accumulation during inflammatory processes were investigated in vivo and in vitro. METHODS:In vivo studies were performed using carrageenin-induced pleurisy in rats pre-treated with PACs. Exudate volu...

journal_title：Journal of inflammation (London, England)

authors： Garbacki N,Kinet M,Nusgens B,Desmecht D,Damas J

更新日期：2005-08-09 00:00:00

abstract：:Adult bone marrow derived mesenchymal stem cells offer the potential to open a new frontier in medicine. Regenerative medicine aims to replace effete cells in a broad range of conditions associated with damaged cartilage, bone, muscle, tendon and ligament. However the normal process of immune rejection of mismatched a...

journal_title：Journal of inflammation (London, England)

authors： Ryan JM,Barry FP,Murphy JM,Mahon BP

更新日期：2005-07-26 00:00:00

abstract：:The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor thro...

journal_title：Journal of inflammation (London, England)

authors： Smith GR,Missailidis S

更新日期：2004-09-30 00:00:00